Elisabetta Melloni Selected Research

nutlin 3

7/2022	Editor's Note: Dasatinib Plus Nutlin-3 Shows Synergistic Antileukemic Activity in Both p53wild-type and p53mutated B Chronic Lymphocytic Leukemias by Inhibiting the Akt Pathway.
10/2016	Ibrutinib synergizes with MDM-2 inhibitors in promoting cytotoxicity in B chronic lymphocytic leukemia.
6/2014	Sodium dichloroacetate exhibits anti-leukemic activity in B-chronic lymphocytic leukemia (B-CLL) and synergizes with the p53 activator Nutlin-3.
12/2013	The MDM2 inhibitor Nutlin-3 attenuates streptozotocin-induced diabetes mellitus and increases serum level of IL-12p40.
11/2012	The sorafenib plus nutlin-3 combination promotes synergistic cytotoxicity in acute myeloid leukemic cells irrespectively of FLT3 and p53 status.
2/2011	Dasatinib plus Nutlin-3 shows synergistic antileukemic activity in both p53 wild-type and p53 mutated B chronic lymphocytic leukemias by inhibiting the Akt pathway.
3/2010	The oncogene DEK promotes leukemic cell survival and is downregulated by both Nutlin-3 and chlorambucil in B-chronic lymphocytic leukemic cells.
4/2009	Nutlin-3 up-regulates the expression of Notch1 in both myeloid and lymphoid leukemic cells, as part of a negative feedback antiapoptotic mechanism.
2/2008	Combined treatment of CpG-oligodeoxynucleotide with Nutlin-3 induces strong immune stimulation coupled to cytotoxicity in B-chronic lymphocytic leukemic (B-CLL) cells.
10/2007	The MDM-2 antagonist nutlin-3 promotes the maturation of acute myeloid leukemic blasts.

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Elisabetta Melloni Research Topics

Disease

13	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 07/2022 - 04/2006
8	Neoplasms (Cancer) 03/2022 - 01/2008
6	Inflammation (Inflammations) 04/2021 - 04/2013
5	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 11/2012 - 08/2003
2	Atherosclerotic Plaque (Atheroma) 01/2021 - 01/2018
1	Virus Diseases (Viral Diseases) 03/2022
1	Primary Myelofibrosis (Myelosclerosis) 03/2022
1	Cytokine Release Syndrome 03/2022
1	Polycythemia (Erythrocytosis) 03/2022
1	Graft vs Host Disease (Graft-Versus-Host Disease) 03/2022
1	Neurodegenerative Diseases (Neurodegenerative Disease) 04/2021
1	Mevalonate Kinase Deficiency 01/2021
1	Multiple Sclerosis 01/2021
1	Vitamin D Deficiency 01/2021
1	Colorectal Neoplasms (Colorectal Cancer) 03/2020
1	Colonic Neoplasms (Colon Cancer) 03/2020
1	Obesity 08/2019
1	Hepatocellular Carcinoma (Hepatoma) 08/2019
1	Necrosis 01/2019
1	Kidney Diseases (Kidney Disease) 01/2019
1	Diabetic Nephropathies (Diabetic Nephropathy) 01/2019
1	Fibrosis (Cirrhosis) 01/2019
1	Pathologic Processes 01/2018
1	Refractive Errors (Refractive Error) 01/2015
1	Diabetes Mellitus 12/2013
1	Squamous Cell Carcinoma (Epidermoid Carcinoma) 12/2012
1	Squamous Cell Carcinoma of Head and Neck 04/2012
1	Lymphoma (Lymphomas) 06/2010
1	Hematologic Neoplasms (Hematological Malignancy) 04/2009
1	Neoplasm Metastasis (Metastasis) 01/2008
1	Carcinogenesis 01/2008
1	Anemia 02/2005
1	Myelodysplastic Syndromes (Myelodysplastic Syndrome) 02/2005
1	Bone Resorption 10/2004
1	Idiopathic Thrombocytopenic Purpura (Thrombocytopenic Purpura, Autoimmune) 05/2002

Drug/Important Bio-Agent (IBA)

11	nutlin 3IBA 07/2022 - 05/2007
5	CytokinesIBA 01/2018 - 02/2005
4	TNF-Related Apoptosis-Inducing LigandIBA 01/2018 - 08/2003
3	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2018 - 08/2003
2	Dasatinib (BMS 354825)FDA Link 07/2022 - 02/2011
2	ibrutinibIBA 01/2021 - 10/2016
2	NF-kappa B (NF-kB)IBA 01/2019 - 08/2003
2	Biomarkers (Surrogate Marker)IBA 01/2019 - 04/2013
2	C-Reactive ProteinIBA 01/2018 - 04/2013
2	Messenger RNA (mRNA)IBA 12/2012 - 05/2011
1	ruxolitinibIBA 03/2022
1	Bile Acids and Salts (Bile Acids)IBA 01/2022
1	mitoquinoneIBA 04/2021
1	Reactive Oxygen Species (Oxygen Radicals)IBA 04/2021
1	Farnesyl-Diphosphate Farnesyltransferase (Squalene Synthase)IBA 01/2021
1	Triglycerides (Triacylglycerol)IBA 01/2021
1	Phosphorus (Red Phosphorus)IBA 01/2021
1	1- ((1- (3- acetoxy- 2,2- dimethylpropyl)- 7- chloro- 5- (2,3- dimethoxyphenyl)- 2- oxo- 1,2,3,5- tetrahydro- 4,1- benzoxazepin- 3- yl)acetyl)piperidine- 4- acetic acidIBA 01/2021
1	Vitamin D FDA LinkGeneric 01/2021
1	CalciumIBA 01/2021
1	CholesterolIBA 01/2021
1	SelectinsIBA 01/2021
1	paricalcitol (Zemplar)FDA Link 01/2021
1	Apolipoproteins E (ApoE)IBA 01/2021
1	MetalsIBA 03/2020
1	OxidesIBA 03/2020
1	PowdersIBA 03/2020
1	Tumor Biomarkers (Tumor Markers)IBA 03/2020
1	AdipokinesIBA 08/2019
1	Aryldialkylphosphatase (Paraoxonase)IBA 08/2019
1	ResistinIBA 08/2019
1	Transcription Factors (Transcription Factor)IBA 01/2019
1	LigandsIBA 01/2018
1	Ceruloplasmin (Ferroxidase)IBA 01/2018
1	Metformin (Glucophage)FDA LinkGeneric 04/2016
1	purineIBA 02/2015
1	Dichloroacetic AcidIBA 06/2014
1	Streptozocin (Streptozotocin)FDA Link 12/2013
1	Interleukin-12 Subunit p40IBA 12/2013
1	DNA (Deoxyribonucleic Acid)IBA 12/2012
1	Sorafenib (BAY 43-9006)FDA Link 11/2012
1	Phosphotransferases (Kinase)IBA 11/2012
1	Drug CombinationsIBA 11/2012
1	Therapeutic UsesIBA 04/2012
1	Chlorambucil (Leukeran)FDA Link 03/2010
1	Gamma Secretase Inhibitors and ModulatorsIBA 04/2009
1	OligodeoxyribonucleotidesIBA 02/2008
1	CPG-oligonucleotideIBA 02/2008
1	IsoenzymesIBA 01/2008
1	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 01/2008
1	Phorbol EstersIBA 01/2008
1	Protein Isoforms (Isoforms)IBA 01/2008
1	Surface Antigens (Surface Antigen)IBA 10/2007
1	Interleukin-8 (Interleukin 8)IBA 04/2006
1	CD40 Ligand (CD40L)IBA 04/2006
1	Tartrate-Resistant Acid PhosphataseIBA 10/2004
1	Macrophage Colony-Stimulating FactorIBA 10/2004

Therapy/Procedure

2	Therapeutics 02/2015 - 01/2008
1	Immunotherapy 03/2022
1	Hematopoietic Stem Cell Transplantation 03/2022
1	Cell- and Tissue-Based Therapy (Cell Therapy) 03/2022
1	Aftercare (After-Treatment) 01/2021
1	Injections 01/2021
1	Photorefractive Keratectomy 01/2015
1	Peripheral Blood Stem Cell Transplantation (Peripheral Stem Cell Transplantation) 05/2002